The 49ers are faced with replacing another key starter, as FS Adrian Colbert has been placed on IR with a high-ankle sprain. The injury is expected to keep him sidelined for about 6-8 weeks, according to head coach Kyle Shanahan. Rookie D.J. Reed is expecting to fill in for Colbert in the lineup.

Colbert was injured when he collided with CB Ahkello Witherspoon when they both went up to try to intercept the ball (neither of them came down with it).

QB Tom Savage spent the last week with the team before being waived just before the weekend in exchange for DB Tyvis Powell.